Article
The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis.
Molecular neurobiology - 1 Sept 2023
Davidson Jennilee M, Wu Sharlynn S L, Rayner Stephanie L, Cheng Flora, Duncan Kimberley, Russo Carlo, Newbery Michelle, Ding Kunjie, Scherer Natalie M, Balez Rachelle, García-Redondo Alberto, Rábano Alberto, Rosa-Fernandes Livia, Ooi Lezanne, Williams Kelly L, Morsch Marco, Blair Ian P, Di Ieva Antonio, Yang Shu, Chung Roger S, Lee Albert
Abstract excerpt
Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the cyclin F-E3 ligase complex SCFcyclinF known to ubiquitylate substrates for proteasomal degradation. In this study, we identified a function of cyclin F to regulate substrate solubility and show how cyclin F...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.