Article

Chronic RNA G-quadruplex accumulation in aging and Alzheimer’s disease

2025-02-24

Abstract excerpt

As the world population ages, new molecular targets in aging and Alzheimer’s disease (AD) are needed to combat the expected influx of new AD cases. Until now, the role of RNA structure in aging and neurodegeneration has largely remained unexplored. In this study, we examined human hippocampal postmortem tissue for the formation of RNA G-quadruplexes (rG4s) in aging and AD. We found that rG4 immunostaining strongly...

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Literature Corpus work: 26a51a9b-aef6-5ebb-b773-c86833060518
DOI: 10.7554/elife.105446.3

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