Article

Chronic RNA G-quadruplex Accumulation in Aging and Alzheimer’s Disease

2023-10-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> As the world population ages, new molecular targets in aging and Alzheimer’s Disease (AD) are needed to combat the expected influx of new AD cases. Until now, the role of RNA structure in aging and neurodegeneration has largely remained unexplored. <h4>METHODS</h4> In this study, we examined human hippocampal postmortem tissue for the formation of RNA G-quadruplexes (rG4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68df98ee-878f-5b94-9443-e83ae4ac98d2
DOI: 10.1101/2023.10.02.560545

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic RNA G-quadruplex Accumulation in Aging and Alzheimer’s DiseaseDOI 10.1101/2023.10.02.560545Read

Chronic RNA G-quadruplex accumulation in aging and Alzheimer’s diseaseSemantic proximity Read

Molecular and structural remodeling of stress granules in slowly and rapidly progressive Alzheimer’s diseaseSemantic proximity Read

m⁶A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer’s diseaseSemantic proximity Read

Identification of circRNAs linked to Alzheimer’s disease and related dementiasSemantic proximity Read

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's diseaseSemantic proximity Read

Deep Profiling of the Aggregated Proteome in Alzheimer’s Disease: From Pathology to Disease MechanismsSemantic proximity Read

Small RNA modifications in Alzheimer’s diseaseSemantic proximity Read

Emerging role of RNA•DNA hybrids inC9orf72-linked neurodegenerationSemantic proximity Read

Sublethal RNA Oxidation as a Mechanism for Neurodegenerative DiseaseSemantic proximity Read

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s diseaseSemantic proximity Read

Temporal and Regional Circular RNA profiling in a Tauopathy Mouse Model: Implications for Tau Pathology and NeurodegenerationSemantic proximity Read

Identification of circRNAs linked to Alzheimer's disease and related dementiasSemantic proximity Read