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Article

Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors

2 Dec 2021

Abstract excerpt

Due to limitations in local therapy approaches for sinonasal tumors, improvement in systemic therapies plays a pivotal role for prolongation of the patient’s survival. The aim of this study was to examine potential biomarkers, including deficiency in mismatch repair proteins (dMMR)/microsatellite instability (MSI-H) in sinonasal cancers and their precancerous lesions. A comprehensive analysis of 10 sinonasal...

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PMID: 34885191
DOI: 10.3390/cancers13236081

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