Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature.

doi:10.1038/s41379-022-01122-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2022

Chłopek Małgorzata, Lasota Jerzy, Thompson Lester D R, Szczepaniak Magdalena, Kuźniacka Alina, Hińcza Kinga, Kubicka Kamila, Kaczorowski Maciej, Newford Michael, Liu Yalan, Agaimy Abbas, Biernat Wojciech, Durzyńska Monika, Dziuba Ireneusz, Hartmann Arndt, Inaguma Shingo, Iżycka-Świeszewska Ewa, Kato Hiroyuki, Kopczyński Janusz, Michal Michal, Michal Michael, Pęksa Rafał, Prochorec-Sobieszek Monika, Starzyńska Anna, Takahashi Satoru, Wasąg Bartosz, Kowalik Artur, Miettinen Markku

Abstract excerpt

Sinonasal mucosal melanoma is a rare tumor arising within the nasal cavity, paranasal sinuses, or nasopharynx (sinonasal tract). This study evaluated 90 cases diagnosed in 29 males and 61 females with median age 68 years. Most tumors involved the nasal cavity and had an epithelioid morphology. Spectrum of research techniques used in this analysis includes targeted-DNA and -RNA next-generation sequencing, Sanger...

Topics

Male
Female
Humans
Aged
Proto-Oncogene Proteins B-raf
In Situ Hybridization, Fluorescence
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Paranasal Sinus Neoplasms

Mutation

Signal Transduction

Paranasal Sinuses

Class I Phosphatidylinositol 3-Kinases

TOR Serine-Threonine Kinases

RNA

Molecular Biology

DNA Mutational Analysis

Source

Open in PubMed

Identifiers

PMID: 35978013
DOI: 10.1038/s41379-022-01122-7

Genes

BRAF
NRAS
NF1
SPRED1
TP53
AMER1
APC
CTNNB1
MDM2
NUMBL
PIK3CA
PTEN
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature.PMID 35978013Read ↗

Sinonasal mucosal melanoma: Molecular profile and therapeutic implications from a series of 32 cases.Semantic proximity Read ↗

SF3B1, NRAS, KIT, and BRAF Mutation; CD117 and cMYC Expression; and Tumoral Pigmentation in Sinonasal MelanomasSemantic proximity Read ↗

Mutation status among patients with sinonasal mucosal melanoma and its impact on survivalSemantic proximity Read ↗

KIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases.Semantic proximity Read ↗

Targeted next-generation sequencing of Japanese patients with sinonasal mucosal melanomas identifies frequent NRAS and CTNNB1 mutations.Semantic proximity Read ↗

Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations.Semantic proximity Read ↗

BRAF, NRAS, KIT, TERT, GNAQ/GNA11 mutation profile analysis of head and neck mucosal melanomas: a study of 42 cases.Semantic proximity Read ↗

Gene mutations and clinical prognosis of mucosal melanoma in different locations of head and neck.Semantic proximity Read ↗

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targetsSemantic proximity Read ↗

Expanding the Molecular Landscape of Deep Penetrating Nevus-like Melanomas Beyond CTNNB1 and APC Mutations : A Clinicopathologic and Molecular Study of 14 Cases.Semantic proximity Read ↗

TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas.Semantic proximity Read ↗

Ras, Raf, and MAP kinase in melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.