Article

Solid Tumors in RASopathies: Insights from a Large Monocentric Cohort and Systematic Review of the Literature

2025-11-19

Abstract excerpt

<title>Abstract</title> <p> Background. The RAS-MAPK signaling cascade mediates cellular responses to external stimuli, regulating key processes involved in tumorigenesis, including growth, differentiation, and survival. RASopathies are a group of neurodevelopmental disorders caused by dysregulated RAS-MAPK activity and characterized by overlapping clinical presentations. While individuals with Neurofibromatosis...

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Literature Corpus work: 1447fdde-2cdc-5baf-ba31-aa849c37695f
DOI: 10.21203/rs.3.rs-7979959/v1

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