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Article

Global pattern of CD8+ T cell infiltration and exhaustion in colorectal cancer predicts cancer immunotherapy response

2020-10-12

Abstract excerpt

<title>Abstract</title> <p>MSI/MSS status does not fully explain cancer immunotherapy response in colorectal cancer. We used gene expression data of 454 samples (MSI=131, MSI-L=23, MSS=284, Unknown=16) and developed a method TMEPRE that models colorectal cancer specific signature of CD8+ T cell infiltration and CD8+ T cell exhaustion states. TMEPRE showed predictive power in three datasets of anti-PD1 treated pat...

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Literature Corpus work
267c8795-e9b6-5b0d-90d8-e21431de8dad
DOI
10.21203/rs.3.rs-89397/v1
Open publication

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Global pattern of CD8+ T cell infiltration and exhaustion in colorectal cancer predicts cancer immunotherapy responseDOI 10.21203/rs.3.rs-89397/v1
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