Article

Decoding the Role of H19 in Cholestatic Liver Injury Using snRNA-seq, Spatial Transcriptomics, and Machine Learning-Based Disease Prediction

2026-01-14

Abstract excerpt

<title>Abstract</title> <p> Background Primary Sclerosing Cholangitis (PSC) is a chronic obstructive biliary disease and remains a high-burden cholestatic liver disease with no approved therapies and a substantial recurrence rate following liver transplantation. The long non-coding RNA H19 (H19) has emerged as a potential driver of PSC progression, yet its cell-type-specific and spatially resolved mechanisms re...

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Literature Corpus work: 2630d63d-0199-5cce-b1b5-cdcd8358c5a8
DOI: 10.21203/rs.3.rs-8339668/v1

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