Article
Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge.
PloS one - 1 Jan 2017
Elam Marshall B, Majumdar Gipsy, Mozhui Khyobeni, Gerling Ivan C, Vera Santiago R, Fish-Trotter Hannah, Williams Robert W, Childress Richard D, Raghow Rajendra
Abstract excerpt
Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are generally well tolerated, up to ten percent of statin-treated patients experience myalgia symptoms, defined as muscle pain without elevated creatinine phosphokinase (CPK) levels. Myalgia is the most frequent reason for discontinuation of statin therapy. The...
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