Back to search

Article

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

2020-09-23

Abstract excerpt

Mutations and transient conformational movements of receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable, present immune escape routes to SARS-CoV-2. To mitigate viral escape, we developed a cocktail of neutralizing antibodies (NAbs) targeting epitopes located on different domains of spike (S) protein. Screening of a library of monoclonal antibodies generated from peripheral blood...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
94e95c35-af6a-5f0b-8b91-3e4465454fa6
DOI
10.1101/2020.09.23.309294
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2DOI 10.1101/2020.09.23.309294
Identification of B-Cell Epitopes for Eliciting Neutralizing Antibodies against the SARS-CoV-2 Spike Protein through Bioinformatics and Monoclonal Antibody TargetingSemantic proximity
Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational lockingSemantic proximity
Incorporation of Sars-Cov-2 Spike Ntd to Rbd-Based Vaccine Improves Immunity and Protection Against Viral VariantsSemantic proximity
Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopesSemantic proximity
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium studySemantic proximity
Design of SARS-CoV-2 RBD Immunogens to Focus Immune Responses Towards Conserved Coronavirus EpitopesSemantic proximity
A Structural Landscape of Neutralizing Antibodies Against SARS-CoV-2 Receptor Binding DomainSemantic proximity
Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variantsSemantic proximity
Broad Neutralizing Antibodies Against SARS-CoV-2: Current Progress and Engineering Strategies.Semantic proximity
Epitope Analysis of Anti-SARS-CoV-2 Neutralizing Antibodies.Semantic proximity
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSemantic proximity
Antibody repertoire induced by SARS-CoV-2 spike protein immunogensSemantic proximity
Select a neighboring publication to make it the new centre.