Article

Real-Time Course: Reconstruction of cellular diversity and lineage trajectory based on somatic mutational patterns detected from low-pass single-cell transcriptome data

2022-04-14

Abstract excerpt

Single-cell RNA-seq (scRNA-seq) analysis can describe the states of individual cells but cannot clarify direct relationships between cells. Therefore, we developed a method to trace the progenitor cells of cell differentiation pathways through the cell lineage using somatic mutations detected in low-pass scRNA sequences. Using two human placental tissue datasets, we detected 2,172 and 627 somatic mutation candidat...

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Literature Corpus work: 261d74bb-e0c9-57ab-815c-e507e846e0a9
DOI: 10.21203/rs.3.rs-1558242/v1

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