Article
Temporal lobe epilepsy and matrix metalloproteinase 9: a tempting relation but negative genetic association.
Seizure - 1 Jul 2010
Heuser Kjell, Hoddevik Eystein Hellstrøm, Taubøll Erik, Gjerstad Leif, Indahl Ulf, Kaczmarek Leszek, Berg Paul R, Lien Sigbjørn, Nagelhus Erlend A, Ottersen Ole Petter
Abstract excerpt
OBJECTIVE: Neuroplasticity can be defined as the ability of the brain to adapt to environmental impacts. These adaptations include synapse formation and elimination, cortical reorganization, and neurogenesis. In epilepsy these mechanisms may become detrimental and contribute to disease progression. It has been proposed that Matrix Metalloproteinase 9 (MMP-9), a proteinase that cleaves extracellular matrix...
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