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Article

The TIMPs tango with MMPs and more in the central nervous system

24 Nov 2003

Abstract excerpt

The matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular proteases that have been implicated in CNS development and disease. Crucial homeostatic regulation of MMPs is mediated through the expression and actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the TIMPs are recognized inhibitors of the MMPs, recent studies have revealed that these proteins also can exhibit...

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PMID: 14689443
DOI: 10.1002/jnr.10836

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