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Article

Elevation of MMP-9 Levels Promotes Epileptogenesis After Traumatic Brain Injury.

Molecular neurobiology - 1 Dec 2018

Pijet Barbara, Stefaniuk Marzena, Kostrzewska-Ksiezyk Agnieszka, Tsilibary Photini-Effie, Tzinia Athina, Kaczmarek Leszek

Abstract excerpt

Posttraumatic epilepsy (PTE) is a recurrent seizure disorder that often develops secondary to traumatic brain injury (TBI) that is caused by an external mechanical force. Recent evidence shows that the brain extracellular matrix plays a major role in the remodeling of neuronal connections after injury. One of the proteases that is presumably responsible for this process is matrix metalloproteinase-9 (MMP-9). The...

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Identifiers

PMID: 29667129
DOI: 10.1007/s12035-018-1061-5
PMCID: PMC6208832

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