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Hepatitis B virus X protein modulates upregulation of DHX9 to promote viral DNA replication

12 Dec 2019

Abstract excerpt

Hepatitis B virus (HBV) infection is a major cause of acute and chronic liver diseases. During the HBV life cycle, HBV hijacks various host factors to assist viral replication. In this research, we find that the HBV regulatory protein X (HBx) can induce the upregulation of DExH-box RNA helicase 9 (DHX9) expression by repressing proteasome-dependent degradation mediated by MDM2. Furthermore, we demonstrate that...

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PMID: 31829498
DOI: 10.1111/cmi.13148

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