Article
Dynamics of genetic instability in sporadic and familial colorectal cancer.
Cancer biology & therapy - 1 Jan 2000
Komarova Natalia L, Lengauer Christoph, Vogelstein Bert, Nowak Martin A
Abstract excerpt
Genetic instability is a defining feature of human cancer. In colorectal cancer, two specific types of genetic instabilities have been identified: microsatellite instability (MIN) leads to a 1000-fold increase in the rate of subtle DNA changes, whereas chromosomal instability (CIN) enhances the rate at which gross chromosomal changes occur during cell division. In this paper, we develop a mathematical model for...
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