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Article

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

10 Dec 2020

Abstract excerpt

Background Asthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood. Methods We piloted genome-wide profiling of the enhancer-associated histone modification H3K27ac in BECs from people with asthma ( n = 4) and healthy controls ( n = 3). Results We identified n = 4,321 (FDR <...

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PMID: 33362848
DOI: 10.3389/fgene.2020.585746

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