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A modified oncolytic measles virus exhibits strong immunotherapeutic potential through RIG-I activation by defective viral genomes

2025-11-24

Abstract excerpt

<title>Abstract</title> <p>Live-attenuated measles virus (MV) infects cancer cells through the CD46 receptor, commonly overexpressed in tumors, and replicates preferentially in cells with impaired type I interferon (IFN-I) response. To enhance immune stimulation, we engineered a C protein–deficient MV (MVdeltaC), thus eliminating a key viral antagonist of innate immunity. MVdeltaC exhibited potent oncolytic activ...

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Literature Corpus work
c8b5dc8c-5e69-552c-8a1d-675b2d49e101
DOI
10.21203/rs.3.rs-7774994/v1
Open publication

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A modified oncolytic measles virus exhibits strong immunotherapeutic potential through RIG-I activation by defective viral genomesDOI 10.21203/rs.3.rs-7774994/v1
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