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Single-cell data-driven design of armed oncolytic virus to boost cooperative innate-adaptive immunity against cancer

13 Dec 2024

Abstract excerpt

Oncolytic viruses have been considered promising cancer immunotherapies. However, oncovirotherapy agents impart durable responses in only a subset of cancer patients. Thus, exploring the cellular and molecular mechanisms underlying the heterogeneous responses in patients can provide guidance to develop more effective oncolytic virus therapies. Single-cell RNA sequencing (scRNA-seq) analysis of tumors responsive...

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PMID: 39674886
DOI: 10.1016/j.ymthe.2024.12.017

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