Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2015

Roulstone Victoria, Pedersen Malin, Kyula Joan, Mansfield David, Khan Aadil A, McEntee Grainne, Wilkinson Michelle, Karapanagiotou Eleni, Coffey Matt, Marais Richard, Jebar Adel, Errington-Mais Fiona, Melcher Alan, Vile Richard, Pandha Hardev, McLaughlin Martin, Harrington Kevin J

Abstract excerpt

Reovirus type 3 (Dearing) (RT3D) infection is selective for cells harboring a mutated/activated RAS pathway. Therefore, in a panel of melanoma cell lines (including RAS mutant, BRAF mutant and RAS/BRAF wild-type), we assessed therapeutic combinations that enhance/suppress ERK1/2 signaling through use of BRAF/MEK inhibitors. In RAS mutant cells, the combination of RT3D with the BRAF inhibitor PLX4720...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Oncogene Protein p21(ras)

Share to Oncolytic Virotherapy

Share to Oncolytic Viruses

Share to Reoviridae

Share to Sulfonamides

Source

Open in PubMed Open full text

Identifiers

PMID: 25619724
DOI: 10.1038/mt.2015.15
PMCID: PMC4427871

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress.PMID 25619724Read ↗

Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.Semantic proximity Read ↗

Activated Ras Signaling Pathways and Reovirus Oncolysis: An Update on the Mechanism of Preferential Reovirus Replication in Cancer CellsSemantic proximity Read ↗

Connecting reovirus oncolysis and Ras signaling.Semantic proximity Read ↗

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-κB-regulated immune responseSemantic proximity Read ↗

Antitumor activity of the ERK inhibitor SCH772984 [corrected] against BRAF mutant, NRAS mutant and wild-type melanoma.Semantic proximity Read ↗

Exploring Reovirus Plasticity for Improving Its Use as Oncolytic VirusSemantic proximity Read ↗

Reovirus as a novel oncolytic agentSemantic proximity Read ↗

p38 MAPK Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Virus Capsid Uncoating and Post-Uncoating StepsSemantic proximity Read ↗

Inhibition of MEK-ERK pathway enhances oncolytic vaccinia virus replication in doxorubicin-resistant ovarian cancerSemantic proximity Read ↗

Stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent NF-κB activation.Semantic proximity Read ↗

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cellsSemantic proximity Read ↗

Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.