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DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

23 Feb 2021

Abstract excerpt

BACKGROUND: DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mechanisms of PRIM1 and identify it as a potential molecular target for HCC. METHODS: Hub genes were screened between HCC tissues and normal liver tissues in 3 gene expression omnibus (GEO) datasets...

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PMID: 33622397
DOI: 10.1186/s13578-021-00555-y

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