Article

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

2021-02-17

Abstract excerpt

The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in the receptor-binding site (RBS) are both mutated in lineages first described in South Africa (B.1.351) and Brazil (B.1.1.28.1). The nAbs isolated from SARS-CoV-2 pati...

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Literature Corpus work: 25649fa6-ce26-5200-951c-b6077e7d0009
DOI: 10.1101/2021.02.16.430500

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