Article

Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential

2025-01-20

Abstract excerpt

Conventional human pluripotent stem cells (hPSCs) are widely used to study early embryonic development, generate somatic cells, and model diseases, with differentiation potential aligned to a post-implantation epiblast identity. In the past decade, naive hPSCs, representing a pre-implantation stage, have been derived. Naive hPSCs efficiently differentiate towards embryonic and extraembryonic lineages such as troph...

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Literature Corpus work: c2e087f6-2081-50c8-98e7-03fc24c8df80
DOI: 10.1101/2025.01.17.633522

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