Back to search

Article

Control of Social Withdrawal of Mice Deficient for the Autism Gene <i>Magel2</i> by Restoration of Vasopressin-Oxytocin Dialogue in Septum

2019-10-10

Abstract excerpt

<h4>Summary</h4> Intellectual and social disabilities are common comorbidities in adolescents and adults with Magel2 gene deficiency characterizing the Prader-Willi and Schaaf-Yang neurodevelopmental syndromes. The cellular and molecular mechanisms underlying the risk for autism in these syndromes are unexplored. Here we used Magel2 knockout mice combined with optogenetic/pharmacological tools to characterize d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2537eed7-5864-51b8-baf6-d0f1c01b6ea3
DOI
10.1101/800425
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Control of Social Withdrawal of Mice Deficient for the Autism Gene <i>Magel2</i> by Restoration of Vasopressin-Oxytocin Dialogue in SeptumDOI 10.1101/800425
Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty.Semantic proximity
The Impact of Oxytocin on Neurite Outgrowth and Synaptic Proteins in <i>Magel2</i> -Deficient MiceSemantic proximity
Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across speciesSemantic proximity
Parallel social information processing circuits are differentially impacted in autismSemantic proximity
Investigation of a Novel Mouse Model of Prader-Willi Syndrome with Invalidation of <i>Necdin</i> and <i>Magel2</i>Semantic proximity
Examining the effect of chronic intranasal oxytocin administration on the neuroanatomy and behavior of three autism-related mouse modelsSemantic proximity
Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context mattersSemantic proximity
A truncating mutation of <i>Magel2</i> in the rat modelled for the study of Schaaf-Yang and Prader-Willi syndromes alters select behavioral and physiological outcomesSemantic proximity
Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context mattersSemantic proximity
Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain.Semantic proximity
Deciphering autism heterogeneity: a molecular stratification approach in four mouse modelsSemantic proximity
Selective Vulnerability of Parvocellular Oxytocin Neurons in Social DysfunctionSemantic proximity
Select a neighboring publication to make it the new centre.