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Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50.

Cancer - 15 Oct 2017

Chandrasekharappa Settara C, Chinn Steven B, Donovan Frank X, Chowdhury Naweed I, Kamat Aparna, Adeyemo Adebowale A, Thomas James W, Vemulapalli Meghana, Hussey Caroline S, Reid Holly H, Mullikin James C, Wei Qingyi, Sturgis Erich M

Abstract excerpt

BACKGROUND: Patients with Fanconi anemia (FA) have an increased risk for head and neck squamous cell carcinoma (HNSCC). The authors sought to determine the prevalence of undiagnosed FA and FA carriers among patients with HNSCC as well as an age cutoff for FA genetic screening. METHODS: Germline DNA samples from 417 patients with HNSCC aged <50 years were screened for sequence variants by targeted next-generation...

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Source

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Identifiers

PMID: 28678401
DOI: 10.1002/cncr.30802
PMCID: PMC5853120

Genes

FANCD2
FANCE
FANCL

Provenance

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