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Article

Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer

1 Jul 2023

Abstract excerpt

In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions remain poorly understood. Here, we show spermine inhibits full-length androgen receptor (AR-FL) and androgen receptor...

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Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
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PMID: 37453063
DOI: 10.1016/j.celrep.2023.112798

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