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A combination of systemic mannitol administration and mannitol-modified polyester nanoparticles facilitate gene delivery to the brain through caveolae-mediated endocytosis

2024-08-30

Abstract excerpt

Overcoming the blood-brain barrier (BBB) remains a significant challenge for nucleic acid delivery to the brain. We have explored a combination of mannitol-modified poly (β-amino ester) (PBAE) nanoparticles and systemic mannitol injection for crossing the BBB. We incorporated mannitol in the PBAE polymer for caveolae targeting and also selected monomers that may help avoid delivery to the liver. We also induced ca...

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Identifiers and source

Literature Corpus work
24fec87a-96de-57d8-ac2c-06b696624546
DOI
10.1101/2024.08.29.610249
Open publication

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A combination of systemic mannitol administration and mannitol-modified polyester nanoparticles facilitate gene delivery to the brain through caveolae-mediated endocytosisDOI 10.1101/2024.08.29.610249
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