Article

Mouse brain-wide transgene expression by systemic injection of genetically engineered exosomes: CAP-Exosomes

2022-04-09

Abstract excerpt

The bottleneck in drug discovery for central nervous system diseases is the absence of effective systemic drug delivery technology for delivering therapeutic drugs into the brain. Although some Adeno Associated Virus (AAV) serotype can cross blood brain barrier and deliver virus genome packaged therapeutic DNA (gene) or RNA molecules to brain cells along with other organs, several hurdles have emerged in the AAV9...

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Literature Corpus work: 2024b5d7-7160-54a1-b12a-2cd970fd3a48
DOI: 10.1101/2022.04.06.487362

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