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Article

Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Ambaw Yohannes A, Ljubenkov Peter A, Singh Shubham, Hamed Abdi, Boland Sebastian, Boxer Adam L, Walther Tobias C, Farese Robert V

Abstract excerpt

INTRODUCTION: Biomarkers are essential for monitoring the progression of frontotemporal dementia (FTD). Although dysregulated brain lipid metabolism, particularly sphingolipids enriched in the nervous system, is a key feature of neurodegeneration, plasma lipids remain underexplored as biomarkers compared to imaging and serum proteins. METHODS: We examined plasma lipidomes using liquid chromatography-tandem mass...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40922380
DOI: 10.1002/alz.70631
PMCID: PMC12417310

Genes

GRN
MAPT
TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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