The MET growth signaling complex drives Alzheimer’s Disease-associated brain pathology in aged Shugoshin 1 mouse cohesinopathy model

Abstract excerpt

The understanding on molecular processes toward Late-onset Alzheimer’s Disease (LOAD) has been insufficient to design LOAD intervention drugs. Previously, we discovered transgenic genomic instability model mice Sgo1-/+ accumulate cerebral amyloid-beta in old age. We proposed the “amyloid-beta accumulation cycle” hypothesis, in which cytotoxic, mitogenic and aneuploidgenic amyloid can create an autonomous mitotic c...

Topics

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• Cell Transformation, Neoplastic
• Disease Progression
• Gene Regulatory Networks
• MAP Kinase Signaling System
• Molecular Targeted Therapy
• Receptor, ErbB-2
• Ribosomal Protein S6 Kinases, 90-kDa
• Y-Box-Binding Protein 1

Identifiers and source

Literature Corpus work

24fc035d-e119-5fa0-8556-8330874400f9

DOI

10.1101/2024.03.26.586833