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Article

"Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.

Aging cell - 1 Mar 2020

Rao Chinthalapally V, Asch Adam S, Carr Daniel J J, Yamada Hiroshi Y

Abstract excerpt

The cell cycle and its regulators are validated targets for cancer drugs. Reagents that target cells in a specific cell cycle phase (e.g., antimitotics or DNA synthesis inhibitors/replication stress inducers) have demonstrated success as broad-spectrum anticancer drugs. Cyclin-dependent kinases (CDKs) are drivers of cell cycle transitions. A CDK inhibitor, flavopiridol/alvocidib, is an FDA-approved drug for acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31981470
DOI: 10.1111/acel.13109
PMCID: PMC7059149

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