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Article

YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention.

Oncotarget - 1 May 2011

Davies Alastair H, Dunn Sandra E

Abstract excerpt

Surprisingly little is known about the underlying genetic events that trigger the progression of a normal cell into a cancerous cell. We recently developed a YB-1-driven model of pre-malignancy where we uncovered that the oncogene promotes genomic instability through cell cycle checkpoint slippage and centrosome amplification. In this research perspective, we describe a possible mechanism by which YB-1 instigates...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

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Source

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Identifiers

PMID: 21576761
DOI: 10.18632/oncotarget.276
PMCID: PMC3248184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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