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Article

Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.

BMC cancer - 26 May 2011

Chen Muhan, Huang Jian-Dong, Deng Hong Kui, Dong Suisui, Deng Wen, Tsang Sze Lan, Huen Michael S Y, Chen Leilei, Zan Tong, Zhu Gui-Xia, Guan Xin-Yuan

Abstract excerpt

BACKGROUND: Amplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene eIF-5A2 within the 3q26 region. Functional study has demonstrated the oncogenic role of eIF-5A2 in the initiation and progression of human cancers. In the present study, we aim to investigate the physiological and pathological effect of eIF-5A2 in an eIF-5A2...

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Identifiers

PMID: 21612665
DOI: 10.1186/1471-2407-11-199
PMCID: PMC3118894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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