Article

An ultraconserved pseudo 5' splice site fine-tunes development by regulating alternative splicing within TOR-related pathways

2025-04-18

Abstract excerpt

<title>Abstract</title> <p> Introns have expanded dramatically during evolution, in which ultraconserved RNA motifs may play essential regulatory roles. Sharing the sequence with the actual 5' splice sites (5'SSs), pseudo-5'SSs are widespread in introns but never spliced. We searched homologous introns and identified eight ultraconserved pseudo-5'SSs (UCP-5'SSs). The most conserved one resides in the animal <it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24faaa18-82db-51b4-984e-449c560c4c1b
DOI: 10.21203/rs.3.rs-6393840/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An ultraconserved pseudo 5' splice site fine-tunes development by regulating alternative splicing within TOR-related pathwaysDOI 10.21203/rs.3.rs-6393840/v1Read

The Functional Map of Ultraconserved Regions in Humans, Mice and RatsSemantic proximity Read

The Dark Genome Investigating Pseudogenes and Non-Coding Regions in Genetic RegulationSemantic proximity Read

Alternative splicing of U12-type introns.Semantic proximity Read

Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways.Semantic proximity Read

Unannotated splicing regulatory elements in deep intron space.Semantic proximity Read

The role of a new class of long noncoding RNAs transcribed from ultraconserved regions in cancer.Semantic proximity Read

First intron length in mammals is associated with 5’ exon skipping rateSemantic proximity Read

Pseudouridine guides germline small RNA transport and epigenetic inheritanceSemantic proximity Read

Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.Semantic proximity Read

Introns encode a vast class of Kink-loop RNAs that autoregulate pre-mRNA splicingSemantic proximity Read

RNA-binding protein Miso/CG44249 is crucial for minor splicing during oogenesis in Drosophila.Semantic proximity Read

Diversity and evolution of spliceosomal systems.Semantic proximity Read