Article

8-OxoG in GC-rich Sp1 binding sites enhances gene transcription during adipose tissue development in juvenile mice

2019-02-08

Abstract excerpt

<h4>ABSTRACT</h4> The oxidation of guanine to 8-oxoguanine (8-oxoG) is the most common type of oxidative DNA lesion. There is a growing body of evidence indicating that 8-oxoG is not only pre-mutagenic, but also plays an essential role in modulating gene expression along with its cognate repair proteins. In this study, we investigated the relationship between 8-oxoG formed under intrinsic oxidative stress conditi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24f77120-19e5-5a16-ba33-3fd008e7e21b
DOI: 10.1101/538967

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

8-OxoG in GC-rich Sp1 binding sites enhances gene transcription during adipose tissue development in juvenile miceDOI 10.1101/538967Read

8-OxoG in GC-rich Sp1 binding sites enhances gene transcription in adipose tissue of juvenile miceSemantic proximity Read

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repairSemantic proximity Read

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repairSemantic proximity Read

Transcription activities at 8-oxoG lesions in DNASemantic proximity Read

Tissue- and sex-specific DNA damage tracks aging in rodents and humansSemantic proximity Read

8-oxoguanine causes spontaneous de novo germline mutations in mice.Semantic proximity Read

YBX1 Modulates 8-Oxoguanine Recognition and Repair in DNASemantic proximity Read

Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence.Semantic proximity Read

α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humansSemantic proximity Read

Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanineSemantic proximity Read

Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress.Semantic proximity Read

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.Semantic proximity Read