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Article

8-OxoG in GC-rich Sp1 binding sites enhances gene transcription in adipose tissue of juvenile mice

30 Oct 2019

Abstract excerpt

The oxidation of guanine to 8-oxoguanine (8-oxoG) is the most common type of oxidative DNA lesion. There is a growing body of evidence indicating that 8-oxoG is not only pre-mutagenic, but also plays an essential role in modulating gene expression along with its cognate repair proteins. In this study, we investigated the relationship between 8-oxoG formed under intrinsic oxidative stress conditions and gene...

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PMID: 31666587
DOI: 10.1038/s41598-019-52139-z

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