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Article

Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18.

Molecules and cells - 31 Jan 2021

Lee Hye Seon, Kim Min Wook, Jin Kyeong Sik, Shin Ho-Chul, Kim Won Kon, Lee Sang Chul, Kim Seung Jun, Lee Eun-Woo, Ku Bonsu

Abstract excerpt

Human papillomaviruses (HPVs) cause cellular hyperproliferation-associated abnormalities including cervical cancer. The HPV genome encodes two major viral oncoproteins, E6 and E7, which recruit various host proteins by direct interaction for proteasomal degradation. Recently, we reported the structure of HPV18 E7 conserved region 3 (CR3) bound to the protein tyrosine phosphatase (PTP) domain of PTPN14, a...

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Source

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Identifiers

PMID: 33431714
DOI: 10.14348/molcells.2020.0169
PMCID: PMC7854179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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