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Article

A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation.

Journal of virology - 17 Aug 2020

Hatterschide Joshua, Brantly Alexis C, Grace Miranda, Munger Karl, White Elizabeth A

Abstract excerpt

The human papillomavirus (HPV) E7 oncoprotein is a primary driver of HPV-mediated carcinogenesis. The E7 proteins from diverse HPVs bind to the host cellular nonreceptor protein tyrosine phosphatase type 14 (PTPN14) and direct it for degradation through the activity of the E7-associated host E3 ubiquitin ligase UBR4. Here, we show that a highly conserved arginine residue in the C-terminal domain of diverse HPV E7...

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Source

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Identifiers

PMID: 32581101
DOI: 10.1128/JVI.01024-20
PMCID: PMC7431784

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A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation.PMID 32581101Read ↗

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