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Membrane-Activating Triphenylphosphonium Functionalized Ciprofloxacin for Multidrug Resistant Bacteria

2020-10-06

Abstract excerpt

Multidrug resistant (MDR) bacteria have become a severe problem for public health. Developing new antibiotics for MDR bacteria is difficult, from inception to the clinically approved stage. Here, we have used a new approach; we have modified the antibiotic, ciprofloxacin (CFX), with triphenylphosphonium (TPP, PPh3) moiety via ester- (CFX-ester-PPh3) and amide-coupling (CFX-ester-PPh3), to target bacterial membrane...

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Literature Corpus work
46fe8a09-1b78-5a8f-b2a5-69f5fe0195b4
DOI
10.20944/preprints202010.0116.v1
Open publication

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Membrane-Activating Triphenylphosphonium Functionalized Ciprofloxacin for Multidrug Resistant BacteriaDOI 10.20944/preprints202010.0116.v1
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