Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.

Journal of medicinal chemistry - 25 Aug 2011

Sabatini Stefano, Gosetto Francesca, Manfroni Giuseppe, Tabarrini Oriana, Kaatz Glenn W, Patel Diixa, Cecchetti Violetta

Abstract excerpt

Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of substrate antimicrobial agents. Inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, resulting in a multidrug resistant phenotype. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ciprofloxacin
Share to Drug Synergism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microbial Sensitivity Tests

Share to Models, Chemical

Share to Molecular Structure

Share to Multidrug Resistance-Associated Proteins

Share to Staphylococcus aureus

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 21751791
DOI: 10.1021/jm200370y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.PMID 21751791Read ↗

<i>In Vitro</i> and <i>In Vivo</i> Investigations into the Potential of Quinazoline and Quinoline Derivatives as NorA Efflux Pump Inhibitors Against Resistant <i>Staphylococcus aureus</i> StrainsSemantic proximity Read ↗

Thymoquinone’ potent impairment of multidrug-resistant Staphylococcus aureus NorA efflux pump activitySemantic proximity Read ↗

Identification and characterization of a novel efflux-related multidrug resistance phenotype in Staphylococcus aureus.Semantic proximity Read ↗

Co-development of efflux pump inhibitors with antibiotics on targeting structural and mutational aspects of AcrB subunit.Semantic proximity Read ↗

NorA, Tet(K), MepA, and MsrA Efflux Pumps in Staphylococcus aureus, their Inhibitors and 1,8-Naphthyridine SulfonamidesSemantic proximity Read ↗

Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureusSemantic proximity Read ↗

CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureusSemantic proximity Read ↗

Novel insight into antimicrobial resistance and sensitivity phenotypes associated to qac and norA genotypes in Staphylococcus aureus.Semantic proximity Read ↗

Discovery of Antibiotic ( <i>E</i> )-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3 <i>H</i> )-oneSemantic proximity Read ↗

Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.Semantic proximity Read ↗

Allele-based analysis revealed the critical functions of region 277-297 in the NorA efflux pump of Staphylococcus aureus.Semantic proximity Read ↗

Expression of norA, norB and norC efflux pump genes mediating fluoroquinolones resistance in MRSA isolatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.