Article
Fatty liver and anti-oxidant enzyme activities along with peroxisome proliferator-activated receptors γ and α expressions in the liver of Wilson's disease.
Molecular genetics and metabolism - 1 Nov 2012
Nagasaka Hironori, Miida Takashi, Inui Ayano, Inoue Ikuo, Tsukahara Hirokazu, Komatsu Haruki, Hiejima Eitaro, Fujisawa Tomoo, Yorifuji Tohru, Hiranao Ken-ichi, Okajima Hideaki, Inomata Yukihiro
Abstract excerpt
BACKGROUND: The mechanisms of liver damage and steatosis in Wilson's disease (WD) presenting accumulation of copper generating oxidants remain unclear. Recent studies have shown that peroxisome proliferator-activated receptors (PPARs), in particular PPARs α and γ, regulate fat content of the live...
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