Article
Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models.
Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2020
Mi Xiaoxiao, Li Zhihui, Yan Jian, Li Yingniang, Zheng Jun, Zhuang Zhenjie, Yang Wenjun, Gong Ling, Shi Junping
Abstract excerpt
Wilson's disease is an autosomal recessive disease characterized by excess copper accumulated in the liver and brain. It is caused by mutations in the copper transporter gene ATP7B. However, based on the poor understanding of the transcriptional program involved in the pathogenesis of Wilson's disease and the lack of more safe and efficient therapies, the identification of novel pathways and the establishment of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.