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Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review)

30 May 2025

Abstract excerpt

Copper, an indispensable trace element in living organisms, plays a pivotal role in human physiological processes. Wilson's disease (WD), an inherited disorder of copper metabolism, is caused by mutations in the ATP7B gene. This genetic malfunction disrupts the dynamics of copper transport and metabolism, thereby impairing ceruloplasmin synthesis and copper excretion. The resultant accumulation of copper in...

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PMID: 40476570
DOI: 10.3892/ijmm.2025.5558

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