Article

Importin-β specific nuclear transport defects recapitulate phenotypic and transcriptional alterations seen in neurodegeneration

2024-02-16

Abstract excerpt

Defects in Nucleocytoplasmic transport have been implicated as an important neurodegenerative pathway in ALS/FTD. Here, we show that a Nemf R86S mutation results in the disruption of NCT both in vitro and in vivo . These disruptions are specific to Importin-β nuclear import, and result in the nuclear loss and cytoplasmic gain of NEMF, Importin-β, and TDP-43. We show that a transient nuclear import block is capa...

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Identifiers and source

Literature Corpus work: 24b4d236-3405-5d15-be53-834c7bf06cff
DOI: 10.1101/2024.02.14.580338

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