Article

Neuronal Cell-Cycle Re-entry Defines Divergent Outcomes Through Replication-Dependent DNA Damage in ALS

2026-02-16

Abstract excerpt

Cell-cycle dysregulation has emerged as a shared mechanism of neuronal loss across neurodegenerative diseases (NDDs), including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and Parkinson’s disease. In post-mitotic neurons, aberrant reactivation of cell-cycle signaling precedes degeneration, yet the upstream triggers and functional consequences of this process remain poorly defined. Nucleocytoplasmic t...

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Literature Corpus work: fcb7b595-ca14-5676-bd35-d1855d9ece82
DOI: 10.64898/2026.02.13.705790

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