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Article

NEMF mutations in mice illustrate how Importin-β specific nuclear transport defects recapitulate neurodegenerative disease hallmarks.

PLoS genetics - 1 Sept 2024

Plessis-Belair Jonathan, Ravano Kathryn, Han Ellen, Janniello Aubrey, Molina Catalina, Sher Roger B

Abstract excerpt

Pathological disruption of Nucleocytoplasmic Transport (NCT), such as the mis-localization of nuclear pore complex proteins (Nups), nuclear transport receptors, Ran-GTPase, and RanGAP1, are seen in both animal models and in familial and sporadic forms of amyotrophic lateral sclerosis (ALS), frontal temporal dementia and frontal temporal lobar degeneration (FTD\FTLD), and Alzheimer's and Alzheimer's Related...

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Identifiers

PMID: 39312574
DOI: 10.1371/journal.pgen.1011411
PMCID: PMC11449308

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