Article

Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS

2025-01-28

Abstract excerpt

Cytoplasmic TDP43 mislocalization and aggregation are pathological hallmarks of amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 mislocalization remain unclear. In this study, we demonstrate that Nemo-like kinase (NLK)—a proline-directed serine/threonine kinase—promotes the mislocalization of TDP43 and other RNA-binding proteins by disrupting nuclear import. NLK levels...

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Identifiers and source

Literature Corpus work: 9c5f99f0-8fb2-565a-9289-f44c35145880
DOI: 10.1101/2025.01.27.635090

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