Article

scPheno: A deep generative model to integrate scRNA-seq with disease phenotypes and its application on prediction of COVID-19 pneumonia and severe assessment

2022-06-21

Abstract excerpt

Cell-to-cell variability is orchestrated by transcriptional variations participating in different biological processes. However, the dissection of transcriptional variability in specific biological process at single-cell level remains unavailable. Here, we present a deep generative model scPheno to integrate scRNA-seq with disease phenotypes to unravel the invisible phenotype-related transcriptional variations. We...

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Literature Corpus work: 24a06b11-ee93-5864-84c8-40a9a2c72c35
DOI: 10.1101/2022.06.20.496916

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