Article
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.
Cell research - 1 Mar 2021
Wauters Els, Van Mol Pierre, Garg Abhishek Dinkarnath, Jansen Sander, Van Herck Yannick, Vanderbeke Lore, Bassez Ayse, Boeckx Bram, Malengier-Devlies Bert, Timmerman Anna, Van Brussel Thomas, Van Buyten Tina, Schepers Rogier, Heylen Elisabeth, Dauwe Dieter, Dooms Christophe, Gunst Jan, Hermans Greet, Meersseman Philippe, Testelmans Dries, Yserbyt Jonas, Tejpar Sabine, De Wever Walter, Matthys Patrick, Neyts Johan, Wauters Joost, Qian Junbin, Lambrechts Diether
Abstract excerpt
How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung. We use pseudotime inference to build T-cell and monocyte-to-macrophage...
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