Article

A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice

2024-07-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Genome wide association studies have identified an exon 6 CTRB2 deletion variant that associates with increased risk of pancreatic cancer. To acquire evidence on its causal role, we developed a new mouse strain carrying an equivalent variant in Ctrb1 , the mouse orthologue of CTRB2 . <h4>Design</h4> We used CRISPR/Cas9 to introduce a 707bp deletion in Ctrb1 encompassing...

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Literature Corpus work: 2451ec80-c0ec-5891-94d8-e9ba567aa9c8
DOI: 10.1101/2024.07.23.604778

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